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Drug

Hydrocortisone

Pronounced

"HYE-droe-KOR-ti-sone"

Uses

Hydrocortisone is a human-made version of a natural substance (cortisol) made by the adrenal gland. This drug is used to treat low cortisol levels caused by diseases of the adrenal gland (such as Addison's disease, adrenocortical insufficiency). Hydrocortisone belongs to a class of drugs known as corticosteroids. Corticosteroids are needed in many ways for the body to function well. They are important for salt and water balance and keeping blood pressure normal.

Other Uses

This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

Hydrocortisone may also be used for arthritis, blood/immune system disorders, skin and eye conditions, breathing problems, cancer, and severe allergies. Hydrocortisone may also be used for COVID-19, but is only effective in hospitalized patients who need extra oxygen or a mechanical ventilator to breathe.

How to Use This Medication

Read the Medication Guide provided by your pharmacist before you start taking hydrocortisone and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually 2 or 3 times daily. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. Drink some water after taking the medication to make sure all the medication is swallowed.

This medication may also be given through a tube into the stomach (gastric tube). If you are giving this medication through a nasogastric or gastric tube, ask your health care professional for detailed instructions on how to give it.

The dosage is based on your medical condition, body size, and response to treatment.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped.

If you suddenly stop using this medication, you may have withdrawal symptoms (such as weakness, weight loss, nausea, muscle pain, headache, tiredness, dizziness). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used hydrocortisone for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal.

Tell your doctor if your condition does not get better or if it gets worse.

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Drug information is selected from data included with permission and copyrighted by First DataBank, Inc. This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional. Always seek the advice of your healthcare professional if you have any questions about this product or your medical condition. This information is not intended as individual medical advice and does not substitute for the knowledge and judgment of your healthcare professional. This information does not contain any assurances that this product is safe, effective or appropriate for you.

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Information expires December 2025.