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Drug

Hydrocortisone

Pronounced

"HYE-droe-KOR-ti-sone"

Uses

Hydrocortisone is a man-made version of a natural substance (cortisol) made by the adrenal gland. This drug is used to treat low cortisol levels caused by diseases of the adrenal gland (such as Addison's disease, adrenocortical insufficiency). Hydrocortisone belongs to a class of drugs known as corticosteroids. Corticosteroids are needed in many ways for the body to function well. They are important for salt and water balance and keeping blood pressure normal.

Other Uses

This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

Hydrocortisone may also be used for arthritis, blood/immune system disorders, skin and eye conditions, breathing problems, cancer, and severe allergies. Hydrocortisone may also be used for COVID-19, but is only effective in hospitalized patients who need extra oxygen or a mechanical ventilator to breathe.

How to Use This Medication

Read the Medication Guide and Instructions for Use provided by your pharmacist before you start taking hydrocortisone and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually 2 or 3 times a day. Take it with food or milk to prevent stomach upset. This medication comes as granules inside a capsule. Do not swallow the capsules whole. Make sure not to get the capsules wet. To use this medication, open the capsule first. You may take this medication by pouring it directly on your tongue, or by pouring it on a spoon and placing the medication in your mouth, or by sprinkling the granules onto a spoonful of cold or room-temperature soft food (such as yogurt or applesauce) before taking the medication. Do not mix the granules in liquid. Do not chew or crush the granules. If taking with soft food, make sure to swallow the mixture within 5 minutes after preparing. Drink some fluids (such as water, milk) after taking the granules to make sure all the medication is swallowed.

This medication should not be given through a feeding tube.

The dosage is based on your medical condition, body size, and response to treatment.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased. If you vomit or spit up after taking a dose, contact your doctor to see if you need to take another dose.

If you suddenly stop using this medication, you may have withdrawal symptoms (such as weakness, weight loss, nausea, muscle pain, headache, tiredness, dizziness). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used hydrocortisone for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal.

Tell your doctor if your condition does not get better or if it gets worse.

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RxAnswers™ is a copyrighted combined product from TraceGains and First DataBank, Inc.

Drug information is selected from data included with permission and copyrighted by First DataBank, Inc. This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your healthcare professional. Always seek the advice of your healthcare professional if you have any questions about this product or your medical condition. This information is not intended as individual medical advice and does not substitute for the knowledge and judgment of your healthcare professional. This information does not contain any assurances that this product is safe, effective or appropriate for you.

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Information expires December 2025.